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  • image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/
    Authors: Pérez Martín, Inmaculada;

    Les nombreuses contributions de Michel Kaplan portant sur l’administration monastique du xie siècle et, en particulier, sur les responsables de la gestion économique des monastères constituent le point de départ des réflexions que nous allons exposer dans le présent travail. Ses études nous donneront l’occasion d’expliquer le changement culturel induit par les conditions socio-économiques, un exercice particulièrement intéressant du fait que le contexte de la production livresque à Byzance re...

    image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/ OpenEditionarrow_drop_down
    image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/
    OpenEdition
    Book . 2019
    Data sources: OpenEdition
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      image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/
      OpenEdition
      Book . 2019
      Data sources: OpenEdition
  • image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/
    Authors: PEHLİVANLI, Hamit;

    Milletlerarası ilişkilerin bir dışarıya akseden açık tarafı, bîr de gözükmeyen sütre gerisi vardır. Sütre gerisini dışişleri yetkilileri, çok az sayıda bir kısım devlet görevlileri ve bir de gizli servis elemanları bilebilirler. Hatta hadiselerin olgunlaşmasını, yön değiştirmesini taraf ülkelerin kendi arzuları doğrultusunda gelişmelerini sağlamada en büyük pay sahiplerinin başında istihbarat teşkilâtları gelmektedir. Bu kuruluşlar olaylar hakkında en doğru bilgileri, ulaşılması güç bilgileri toplar ve yetkililere ulaştırır. Onlardan aldıkları talimatlar çerçevesinde olayları yönlendirir. Bunun için de propaganda yaparlar, her türlü yolu deneyerek hadiseleri kendi inisiyatiflerine almaya gayret ederler. Karşı ülkenin yanlış politikalar oluşturmasına, stratejiler tesbitine katkıda bulunacak yeni haberler, eksik bilgiler yaymak suretiyle kendi amaçlarına hizmet ederler. İkinci Dünya Harbi yıllarında klasik istihbarat anlayışında büyük Ölçüde değişimler göze çarpmaktadır. Top yekûn harp kavramına bağlı olarak top yekûn casusluk anlayışı da ortaya çıkmıştır. Bu anlayışa göre sadece askerî istihbarat ile yetinilmemeli, her alanda bilgi toplanılmahdır. Bu bakımdan Birinci Dünya Harbinde orta seviyede bulunan istihbarat servisinin yerini İkinci Dünya Harbİ'nde muazzam işler gören servisler aldı. Bu stratejiyi ilk defa ve başarı ile uygulayanlar ise Almanlar oldu. Naziler top yekûn casusluk prensiplerine göre çalıştılar ve büyük ölçüde de başarılı oldular. Bu yeni anlayışa göre bir memleketin başında bulunanlar muhasımların askerî ve diğer her türlü, kuvvetini öğrenebilineli ve onların mukavemet derecelerini hesaplayabilmelidirler. 1 Bu kadar karmaşık ve ciddi bir iş olan İstihbaratın önemini de Napolyan "Bir casus yerinde ve zamanında cephedeki binlerce askere denktir." diyerek veciz bir şekilde açıklamıştır

    image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/ Atatürk Araştırma Me...arrow_drop_down
    image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/
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      image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/ Atatürk Araştırma Me...arrow_drop_down
      image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/
  • image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/
    Authors: Xue Qiao; Li Zhu; Rongbo Song; Chao Shang; +1 Authors

    Oral squamous cell carcinoma (OSCC) is the most prevalent malignant tumor in head and neck region. Platinum drug resistance limits the clinical application of chemotherapy regardless of medical development. The aim of our study is to identify cisplatin-resistant genes which can be used as new therapeutic targets and investigate the functional mechanism of OSCC chemoresistance.The OSCC Cal27 and HSC4 cisplatin-resistant cell lines were constructed to screen the differential genes/transcripts expression. GO, KEGG and GSEA were performed to reveal the relevant signaling pathways. Alternative splicing (AS) software rMATs was applied to explore AS events in chemoresistance. R package and TIMER tools were used to evaluate the linear correlation between CD44 and immune cell subpopulations. The co-culture model of dendritic cells (DCs) and OSCC cells was applied to explore the effect of CD44 on immune microenvironment and cisplatin resistance.Our results showed that CD44 was differentially expressed in cisplatin-resistant OSCC cells. Through bioinformatics prediction and experimental verification, we confirmed that CD44 occurring AS was involved in tumor progression and cisplatin resistance. Moreover, CD44 could further enhance the cisplatin resistance of OSCC by activating DCs, making CD44 to be a potential intervention target. We also identified DC as a new target for platinum drugs to stimulate the growth of OSCC.Our findings not only make it possible to explore new therapeutic methods, such as CD44 inhibitors or antisense oligonucleotides, but also provide insights into the new mechanisms of cisplatin resistance to chemotherapy.

    image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/ Translational Oncolo...arrow_drop_down
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    image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/
    Translational Oncology
    Article . 2023 . Peer-reviewed
    License: CC BY NC ND
    Data sources: Crossref
    SSRN Electronic Journal
    Article . 2022 . Peer-reviewed
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      image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/ Translational Oncolo...arrow_drop_down
      image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/
      image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/
      Translational Oncology
      Article . 2023 . Peer-reviewed
      License: CC BY NC ND
      Data sources: Crossref
      SSRN Electronic Journal
      Article . 2022 . Peer-reviewed
      Data sources: Crossref
  • image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/
    Authors: Teresa Nicolosi; Valentina Mariotti; Sahra Talamo; Monica Miari; +7 Authors

    Abstract The present study examines the prehistoric human skeletal remains retrieved starting from the 20s of the XX century in the deposit of the Farneto rock shelter, situated in the area of the ‘Parco dei Gessi Bolognesi e Calanchi dell’Abbadessa’ (San Lazzaro di Savena, Bologna, Northern Italy). An exact dating and a reliable interpretation of the assemblage had not been reached so far because of the lack of contextual data useful for dating purposes, the inaccurate recovery procedures of the remains, as well as their state of preservation. In fact, the skeletal remains from the Farneto rock shelter are highly fragmented and commingled, whereas reliable information about their original position and their recovery procedures are not available. Despite these difficulties, radiocarbon analyses allowed to clarify the precise dating of the remains, which date back to a final phase of the Neolithic and an early phase of the Eneolithic period in Northern Italy, testifying an early use of natural cavities for funerary purposes in the area. Moreover, the anthropological and taphonomic study of the skeletal remains shed light on the biological profile of the individuals and on some events that occurred after their death. In particular, the analysis of peri mortem lesions highlighted the existence of intentional interventions related to corpse treatment, referable to dismembering/disarticulation and scarnification, i.e., cleaning of bones from soft tissues. Finally, the comparison with other Neo/Eneolithic funerary contexts in Central and Northern Italy enabled a better understanding of these complex ritual practices.

    image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/ https://doi.org/10.2...arrow_drop_down
    image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/
    https://doi.org/10.21203/rs.3....
    Preprint . 2022
    License: CC BY
    Data sources: Crossref
    image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/
    Archaeological and Anthropological Sciences
    Article . 2023 . Peer-reviewed
    License: CC BY
    Data sources: Crossref
    image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/
    image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/
    MPG.PuRe
    Article . 2023
    License: CC BY
    Data sources: MPG.PuRe
    Access Routes
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      image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/ https://doi.org/10.2...arrow_drop_down
      image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/
      https://doi.org/10.21203/rs.3....
      Preprint . 2022
      License: CC BY
      Data sources: Crossref
      image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/
      Archaeological and Anthropological Sciences
      Article . 2023 . Peer-reviewed
      License: CC BY
      Data sources: Crossref
      image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/
      image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/
      MPG.PuRe
      Article . 2023
      License: CC BY
      Data sources: MPG.PuRe
  • Authors: Desiderius Erasmus Roterodamus;
    https://doi.org/10.1...arrow_drop_down
    https://doi.org/10.1093/oseo/i...
    Part of book or chapter of book . 1941 . Peer-reviewed
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      https://doi.org/10.1...arrow_drop_down
      https://doi.org/10.1093/oseo/i...
      Part of book or chapter of book . 1941 . Peer-reviewed
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  • Authors: Victor Alba; Antonio Garcia-Baquero Gonzalez;
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  • Authors: Richard B. Kielbowicz; Susan Smulyan;
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  • image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/
    Authors: Jiayun Chen;

    STAR measurements of v1 for identified particles for Au+Au collisions at = 200 GeV are presented. A negative v1 slope is observed for pions, protons, antiprotons and kaons (K0S) in 10-70% central collisions. For pion v1 slope, the comparison between the current result and available models (RQMD, UrQMD, AMPT, QGSM and hydro model with a tilted source) is made. In 5-30% central collisions, surprisingly sizable difference between v1 of protons and antiprotons is observed. The centrality and energy dependence of proton v1 are also presented. The charged hadron v1 for Cu+Cu collisions at = 22.4 GeV is measured and compared with results obtained previously.

    image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/ Journal of Physics :...arrow_drop_down
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    Journal of Physics : Conference Series
    Article . 2011 . Peer-reviewed
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      image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/ Journal of Physics :...arrow_drop_down
      image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/
      Journal of Physics : Conference Series
      Article . 2011 . Peer-reviewed
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  • Authors: David Suchoff;
    https://doi.org/10.9...arrow_drop_down
    https://doi.org/10.9783/978081...
    Part of book or chapter of book . 2012 . Peer-reviewed
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      https://doi.org/10.9...arrow_drop_down
      https://doi.org/10.9783/978081...
      Part of book or chapter of book . 2012 . Peer-reviewed
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  • image/svg+xml Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao Closed Access logo, derived from PLoS Open Access logo. This version with transparent background. http://commons.wikimedia.org/wiki/File:Closed_Access_logo_transparent.svg Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao
    Authors: A. Iranmanesh; B. Khosravi;
    image/svg+xml Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao Closed Access logo, derived from PLoS Open Access logo. This version with transparent background. http://commons.wikimedia.org/wiki/File:Closed_Access_logo_transparent.svg Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao https://doi.org/10.1...arrow_drop_down
    image/svg+xml Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao Closed Access logo, derived from PLoS Open Access logo. This version with transparent background. http://commons.wikimedia.org/wiki/File:Closed_Access_logo_transparent.svg Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao
    https://doi.org/10.1017/cbo978...
    Part of book or chapter of book . 2003 . Peer-reviewed
    License: Cambridge Core User Agreement
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      image/svg+xml Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao Closed Access logo, derived from PLoS Open Access logo. This version with transparent background. http://commons.wikimedia.org/wiki/File:Closed_Access_logo_transparent.svg Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao https://doi.org/10.1...arrow_drop_down
      image/svg+xml Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao Closed Access logo, derived from PLoS Open Access logo. This version with transparent background. http://commons.wikimedia.org/wiki/File:Closed_Access_logo_transparent.svg Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao
      https://doi.org/10.1017/cbo978...
      Part of book or chapter of book . 2003 . Peer-reviewed
      License: Cambridge Core User Agreement
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  • image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/
    Authors: Pérez Martín, Inmaculada;

    Les nombreuses contributions de Michel Kaplan portant sur l’administration monastique du xie siècle et, en particulier, sur les responsables de la gestion économique des monastères constituent le point de départ des réflexions que nous allons exposer dans le présent travail. Ses études nous donneront l’occasion d’expliquer le changement culturel induit par les conditions socio-économiques, un exercice particulièrement intéressant du fait que le contexte de la production livresque à Byzance re...

    image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/ OpenEditionarrow_drop_down
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    OpenEdition
    Book . 2019
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      OpenEdition
      Book . 2019
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    Authors: PEHLİVANLI, Hamit;

    Milletlerarası ilişkilerin bir dışarıya akseden açık tarafı, bîr de gözükmeyen sütre gerisi vardır. Sütre gerisini dışişleri yetkilileri, çok az sayıda bir kısım devlet görevlileri ve bir de gizli servis elemanları bilebilirler. Hatta hadiselerin olgunlaşmasını, yön değiştirmesini taraf ülkelerin kendi arzuları doğrultusunda gelişmelerini sağlamada en büyük pay sahiplerinin başında istihbarat teşkilâtları gelmektedir. Bu kuruluşlar olaylar hakkında en doğru bilgileri, ulaşılması güç bilgileri toplar ve yetkililere ulaştırır. Onlardan aldıkları talimatlar çerçevesinde olayları yönlendirir. Bunun için de propaganda yaparlar, her türlü yolu deneyerek hadiseleri kendi inisiyatiflerine almaya gayret ederler. Karşı ülkenin yanlış politikalar oluşturmasına, stratejiler tesbitine katkıda bulunacak yeni haberler, eksik bilgiler yaymak suretiyle kendi amaçlarına hizmet ederler. İkinci Dünya Harbi yıllarında klasik istihbarat anlayışında büyük Ölçüde değişimler göze çarpmaktadır. Top yekûn harp kavramına bağlı olarak top yekûn casusluk anlayışı da ortaya çıkmıştır. Bu anlayışa göre sadece askerî istihbarat ile yetinilmemeli, her alanda bilgi toplanılmahdır. Bu bakımdan Birinci Dünya Harbinde orta seviyede bulunan istihbarat servisinin yerini İkinci Dünya Harbİ'nde muazzam işler gören servisler aldı. Bu stratejiyi ilk defa ve başarı ile uygulayanlar ise Almanlar oldu. Naziler top yekûn casusluk prensiplerine göre çalıştılar ve büyük ölçüde de başarılı oldular. Bu yeni anlayışa göre bir memleketin başında bulunanlar muhasımların askerî ve diğer her türlü, kuvvetini öğrenebilineli ve onların mukavemet derecelerini hesaplayabilmelidirler. 1 Bu kadar karmaşık ve ciddi bir iş olan İstihbaratın önemini de Napolyan "Bir casus yerinde ve zamanında cephedeki binlerce askere denktir." diyerek veciz bir şekilde açıklamıştır

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    Authors: Xue Qiao; Li Zhu; Rongbo Song; Chao Shang; +1 Authors

    Oral squamous cell carcinoma (OSCC) is the most prevalent malignant tumor in head and neck region. Platinum drug resistance limits the clinical application of chemotherapy regardless of medical development. The aim of our study is to identify cisplatin-resistant genes which can be used as new therapeutic targets and investigate the functional mechanism of OSCC chemoresistance.The OSCC Cal27 and HSC4 cisplatin-resistant cell lines were constructed to screen the differential genes/transcripts expression. GO, KEGG and GSEA were performed to reveal the relevant signaling pathways. Alternative splicing (AS) software rMATs was applied to explore AS events in chemoresistance. R package and TIMER tools were used to evaluate the linear correlation between CD44 and immune cell subpopulations. The co-culture model of dendritic cells (DCs) and OSCC cells was applied to explore the effect of CD44 on immune microenvironment and cisplatin resistance.Our results showed that CD44 was differentially expressed in cisplatin-resistant OSCC cells. Through bioinformatics prediction and experimental verification, we confirmed that CD44 occurring AS was involved in tumor progression and cisplatin resistance. Moreover, CD44 could further enhance the cisplatin resistance of OSCC by activating DCs, making CD44 to be a potential intervention target. We also identified DC as a new target for platinum drugs to stimulate the growth of OSCC.Our findings not only make it possible to explore new therapeutic methods, such as CD44 inhibitors or antisense oligonucleotides, but also provide insights into the new mechanisms of cisplatin resistance to chemotherapy.

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    Translational Oncology
    Article . 2023 . Peer-reviewed
    License: CC BY NC ND
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    SSRN Electronic Journal
    Article . 2022 . Peer-reviewed
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      Translational Oncology
      Article . 2023 . Peer-reviewed
      License: CC BY NC ND
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      SSRN Electronic Journal
      Article . 2022 . Peer-reviewed
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    Authors: Teresa Nicolosi; Valentina Mariotti; Sahra Talamo; Monica Miari; +7 Authors

    Abstract The present study examines the prehistoric human skeletal remains retrieved starting from the 20s of the XX century in the deposit of the Farneto rock shelter, situated in the area of the ‘Parco dei Gessi Bolognesi e Calanchi dell’Abbadessa’ (San Lazzaro di Savena, Bologna, Northern Italy). An exact dating and a reliable interpretation of the assemblage had not been reached so far because of the lack of contextual data useful for dating purposes, the inaccurate recovery procedures of the remains, as well as their state of preservation. In fact, the skeletal remains from the Farneto rock shelter are highly fragmented and commingled, whereas reliable information about their original position and their recovery procedures are not available. Despite these difficulties, radiocarbon analyses allowed to clarify the precise dating of the remains, which date back to a final phase of the Neolithic and an early phase of the Eneolithic period in Northern Italy, testifying an early use of natural cavities for funerary purposes in the area. Moreover, the anthropological and taphonomic study of the skeletal remains shed light on the biological profile of the individuals and on some events that occurred after their death. In particular, the analysis of peri mortem lesions highlighted the existence of intentional interventions related to corpse treatment, referable to dismembering/disarticulation and scarnification, i.e., cleaning of bones from soft tissues. Finally, the comparison with other Neo/Eneolithic funerary contexts in Central and Northern Italy enabled a better understanding of these complex ritual practices.

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    https://doi.org/10.21203/rs.3....
    Preprint . 2022
    License: CC BY
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    Archaeological and Anthropological Sciences
    Article . 2023 . Peer-reviewed
    License: CC BY
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    MPG.PuRe
    Article . 2023
    License: CC BY
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      https://doi.org/10.21203/rs.3....
      Preprint . 2022
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      Archaeological and Anthropological Sciences
      Article . 2023 . Peer-reviewed
      License: CC BY
      Data sources: Crossref
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      MPG.PuRe
      Article . 2023
      License: CC BY
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  • Authors: Desiderius Erasmus Roterodamus;
    https://doi.org/10.1...arrow_drop_down
    https://doi.org/10.1093/oseo/i...
    Part of book or chapter of book . 1941 . Peer-reviewed
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      Part of book or chapter of book . 1941 . Peer-reviewed
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  • Authors: Victor Alba; Antonio Garcia-Baquero Gonzalez;
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  • Authors: Richard B. Kielbowicz; Susan Smulyan;
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    Authors: Jiayun Chen;

    STAR measurements of v1 for identified particles for Au+Au collisions at = 200 GeV are presented. A negative v1 slope is observed for pions, protons, antiprotons and kaons (K0S) in 10-70% central collisions. For pion v1 slope, the comparison between the current result and available models (RQMD, UrQMD, AMPT, QGSM and hydro model with a tilted source) is made. In 5-30% central collisions, surprisingly sizable difference between v1 of protons and antiprotons is observed. The centrality and energy dependence of proton v1 are also presented. The charged hadron v1 for Cu+Cu collisions at = 22.4 GeV is measured and compared with results obtained previously.

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    Journal of Physics : Conference Series
    Article . 2011 . Peer-reviewed
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      Journal of Physics : Conference Series
      Article . 2011 . Peer-reviewed
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  • Authors: David Suchoff;
    https://doi.org/10.9...arrow_drop_down
    https://doi.org/10.9783/978081...
    Part of book or chapter of book . 2012 . Peer-reviewed
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